The role of p-glycoprotein in limiting brain penetration of the peripherally acting anticholinergic overactive bladder drug trospium chloride.

The role of P - glycoprotein in limiting brain penetration of the peripherally acting anticholinergic OAB drug trospium chloride

Trospium chloride: a quaternary amine with unique pharmacologic properties.

The mainstay of pharmacologic treatment of overactive bladder is anticholinergic therapy. Cholinergic blockade is efficacious in decreasing the symptoms of urgency, frequency, and urge incontinence, but also is associated with undesirable side effects such as dry mouth, blurred vision, constipation, and central nervous system side effects. The property of anticholinergic agents that has been as...

Review: anticholinergic drugs improve symptoms but increase dry mouth in adults with overactive bladder syndrome.

Study selection Randomised or quasi-randomised controlled trials in adults with symptomatic diagnosis of overactive bladder syndrome, urodynamic diagnosis of detrusor overactivity, or both, that compared an anticholinergic drug (given to decrease symptoms of overactive bladder) with placebo or no treatment. Studies of darifenacin, emepronium bromide or carrageenate, dicyclomine chloride, oxybut...

Trospium chloride improves overactive bladder symptoms: a multicenter phase III trial.

PURPOSE Trospium chloride is an anticholinergic agent with predominantly peripheral nonselective antimuscarinic activity lacking central nervous system effects. It has no known drug-drug interactions, an advantage for patients taking many medications. Because these qualities may provide added benefit when treating patients with symptoms associated with overactive bladder (OAB) and urge incontin...

Anticholinergics for overactive bladder therapy: central nervous system effects.

The mainstay of pharmacological treatment of overactive bladder (OAB) is anticholinergic therapy using muscarinic receptor antagonists (tertiary or quaternary amines). Muscarinic receptors in the brain play an important role in cognitive function, and there is growing awareness that antimuscarinic OAB drugs may have adverse central nervous system (CNS) effects, ranging from headache to cognitiv...